Mixing may NOT be better-- try it with a mixing console first.
Your two pickups will never be in-phase for all frequencies. There may be a "better" and "less good" phasing. If the rig is always the same and you can re-wire one pickup, OK, Otherwise you may need a phase-switch. In your plan, V1B cathode follower can be changed to a cathodyne offering both phases (actually polarity).
Balance control is way asymmetrical. Suggest R8=240K, R9 200-220K.
Similar issue at R20 R21.
Assuming 1Meg balance pot, assuming -6dB loss at 1/4 or 3/4 turn, you want the resistance feeding the pot near 250K, not 10K. Allow 40K for plate resistance-- 240K-250K from low-Z sources, 200K-220K from plate sources.
I'm confused at V3A. Unity gain to effects loop, but gain of 25 to straight path? Seems like unless FX has large gain, straight will overwhelm FX except when turned to the extreme? Ah, R25 against R20 R21 tends to adjust gain. I'd have to try that to be sure it was smooth and ample. I'd be inclined to abandon the 2-triode plate-mixer at V2 (one triode and 2 resistors can mix) and add some gain after the FX return.
J1 J2 J3 J4 appear to be "PhonE" (1/4") not "PhonO" (RCA) jacks.
Stages have "B+1" etc notes but power supply does not. I'd ass-ume, but I see B+1-5 and 7 nodes on the B+ string. If you know what-goes-where, I'm happy. (I'm not sure why 7 nodes; that's a lot.)
The canonical Fender ToneStack compensates the sound of near-naked strings (nasal). A good acoustic "should" need less compensation, though pick-up-ed acoustic will need more than simply miking for recording. Yes, put Bass Treb to zero, turn MID to full, the Fender TS is fairly flat. So go with it, but I wonder if another plan may be more what the acoustic wants. James? (I'd lean to jacks to insert a $69 7-band graphic EQ... you can't build graf EQ for what they sell for.)
I'm not sure what the levels and gains would/should be for this combination (piezo, hole, mike) and I suspect there will be some adjust-on-test.