Hey Darren,
Hard to tell what your design goals are from the schematic, but in general:
1) Why use 3 triodes in the preamp? Do you have plans for the second half of V2? If not, you could do this circuit with one tube or parallel the 2 halves of of V1, or use V2B for a cathode follower (like a Marshall). Personally, I like to put the tone stack right after the input gain stage rather than after 3 gain stages like you have it.
2) Any particular reason for using a 12AU7 for V1 vs. a 12AX7?
When I want a clean preamp with high headroom I usually just use a high B+ (your 270V to 300V is OK. but 350V is even better), use typical 100K/1K5 for the anode/cathode resistors (center biased) and 22uF to 33uF for the cathode bypass cap (fully bypassed).
If you parallel both halves of V1 for less noise, lower the anode resistor to 51K to maintain center bias (12AX7 values).
3) Any reason for that particular tone stack? Looks pretty lossy. There are lots of tone stacks available, like the Bandmaster and James tone stacks, that have less than 10dB loss, about half of the typical FMV stack. I don't know what yours is.
4) Coupling caps/interstage attenuation - lots of 22nF coupling caps there (pretty small for an input stage), and a voltage divider between V1A and V1B, plus the middle control - all this stuff can add noise to a clean preamp - sometimes I like to use a spilt anode load for V1A, using a 100k pot so I can "dial in" the voltage divider values, then replace with nearest fixed resistors.
Of course you may have considered all of this (and more) when you designed the circuit, but I can't know from just the schematic.
Ken