The dream in my head is a one tube amp.
I've never seen that dream really work out for anyone (myself included.) With a single tube, there's invariably never enough gain for anything more than clean tones so clean that they sound like they come from a solid-state amp. If you so manage to get enough gain for some overdrive (say with a small-signal pentode in the preamp wired for maximum possible voltage gain), then the overdrive is buzzy and sounds like a crude solid-state fuzz-box rather than a good tube amp.
My most recent attempt at this used a 6JW8 triode/pentode in an SE design that put out a whopping 200 milliwatts or so of output power. A sort of micro-Champ, if you wish. Wired to the stock speaker in my '65 PRRI, 200 mW was actually plenty loud enough for use in my apartment, in fact, too loud to overdrive at night without worrying about annoying the neighbours.
I used the 6JW8 pentode as the output tube, with a small Hammond OT with a primary set to around 22 kilo ohms, and B+ around 135 volts. The triode in the 6JW8 was the input stage. One tube, but gain was too low, and all I got was low-volume, too-clean tone.
Then I added a 6AQ6 in front (ignored the two diodes, just used the triode.) With this, I had enough gain to put a two-knob tone stack between triode and pentode stages of the 6JW8, and still go from clean tones to classic-rock levels of overdrive.
I kinda liked it - I think it was a pretty decent all-tube mini amp - but I didn't like it enough to take it beyond the prototype stage.
Each of the two valves cost a whole buck (USD) each, so two bucks total.

I think this little amp has some potential to be turned into a kinda-sorta Herzog, feeding the output to a solid-state power amp or P.A. system. I haven't explored that, though.
Back to one-tube amps, I think the guitar signal has to go through a number of tubes, each adding just a tiny bit of distortion and non-linearity, for a tube amp to sound "tubey". Even classic Fender amps designed only for clean tones (like my '65 PRRI) have the signal go through five tubes before reaching the speaker. A one-tube amp is just not going to sound tubey, and if it doesn't sound tubey, what's the point? Might as well go solid-state at that point.
-Gnobuddy