Comb filtering works a lot like it's namesake- the comb. With lower frequencies it's called the Power Alley (one tooth). The rule for subs is this: closer than three feet between each one or further than 30 feet. It has to do with the wavelength of each tone. In the middle of the "alley" the phase of the two frequencies is additive (they work together) to each side the frequencies work against each other and the it sounds softer. (So, if you go to a gig and the subs are clustered to one side or in the middle- it's a clue that the sound guy knows his stuff.) Moving up the scale, driver placement is even more critical. When drivers are sharing the same frequencies, they need to be mounted within a wavelength of the highest frequency to eliminate the combing effect. I have a line of 27 3/8" dome tweeters that are crossed at about 5kHz. the center to center is about 1.5" which is about 9,000 Hz so the cones are effectively coupled up to 9kHz. above 9K, you get some combing... you can year it as a fluctuation in volume as you play a tone and do some deep knee bends- you don't hear much if your ears stay on the same height relative to the line. It sounds a little wierd with steady tones, but not as noticeable playing most music. It would be much more pronounced if the tweeters were not as close. Mounting a line of horns mouth to mouth is better, because you can get effectively zero center to center spacing because the whole mouth of the horn radiates.
Note: this works only if the line is vertically arrayed- lining up mids or tweeters horizontally is a recipe for disaster. (this is why those "cluster arrays" sound like *expletive deleted*)