12AU7's would totally work in place of the 6SN7's. I jumped to the 6SN7 because of voltage concerns with the PI when it was still a Concertina. By the time I went LTPI, the bread-board was already wired.
The cascode circuit was not a flop. I was just shy of desired gain. I slapped the 12SJ7 circuit in as a comparison and well.... you know your ears can make decisions.
My real battle was with the tone controls. My original idea is not only costly but I was quick to settle on singular values. I've used this James tone stack before in my Kelsey Bass project. It was sandwiched a little differently. Since I now had a shade more gain than necessary and a spare 6SN7, this seemed like a good idea. The cathode follower is somewhat superfluous but doing no harm. The following stage was originally a plate follower matched to recover losses from the tone stack. Something was nasty, perhaps my feedback network was adversely affecting my treble control. Ditching the 2 resistors and cathode bypass cap brought it right.
The icing on the cake is that big honkin' choke. That made such a drastic improvement in noise and dynamic sensitivity. The improvement in sensitivity may easily be a placebo effect from the improved noise floor. Don't care.... I'll take it either way.