All mine run on 6CZ5 tubes. What I have found in studying those tubes closely, is that the RCA 6CZ5 is absolutely identical to the RCA 6973, except for the pinout. The Sylvania 6CZ5 is not and appears less stout in construction. So I concluded that the RCA tube could take the voltage. There is a thread here about that from 2 or so years ago.
I have several Valco amps, as I bought them years ago before eBay buyers realized that Supros were Valcos. Some are noisy, some are not. I have found most of the noise to be around the PI tube. As you said a combination of lead dress and ground issues. But I have also found cleaning the tube sockets helped and also trying different tubes in that position including the whole alphabet of 12_7 tubes. Replacing the input jacks helps too, even though its a pain with that shield Valco used.
Interestingly, (well to me anyway) I have rebuilt two Supro Thunderbolts and two Harmony 420s. Except for the cabinet, all 4 were identical. And the Harmony 420 schematic is accurate, and the various Thunderbolt schematics that are out there were not.

All 4 were quiet well built amps, but with a large chassis and no trem or reverb, there was lots of room for the dog to eat it's breakfast.