I'm very interested in this topic as well. I don't see any reason why you couldn't use any speaker that's otherwise suited for a closed back cabinet. I'm curious, though, about internal baffles and ports. I know there's a compression/rarefaction situation going on with the air inside and outside the cab when the cone moves. This would be the same with the iso cab, but I wonder if a small port or series of ports somewhere in the baffle to equalize the air would help or hurt? I don't mean enough equalization to cancel out the signal, but can the frequency response be tailored in the same way it can with a regular performance cab?
Another thing I'm curious about is internal volume. We generally know that guitar cab dimensions aren't that critical, except as they affect cancellation in an open back cab and bass response in a closed back cab. If the baffle isn't ported in an iso cab, it's an infinite baffle for all practical purposes. Does the air volume affect bass response as much as it would for, say, a 4x12 cab? If so, which space is more critical - the area behind the speaker or in front of it?
I'll search the web on this stuff now that Seth has me thinking, but I'll bet he would like to hear from the voices of experience gathered here as much as I would.