The hum/buzz filtering should be computed for each stage. In general the tolerable hum gets lower as you go toward the input jack, and you can stand more 120Hz than 360Hz or 600Hz, so sequential (not spider) filtering is most economic. Figure your signal level at the plate. You should figure your PSRR but for tube triodes the PSRR is small and can be neglected. Pick a signal/hum ratio. 60dB or 1000:1 will be audible. 80dB or 10,000:1 is very clean on stage or in studio.
Small voltage drops are not the way to go. If you start from 300V, the "headroom" difference between 299V, 290V, and 270V is quite negligible, while the filtering/$ improves 10 or 30 times. If a 10% drop "matters", you should consider lower working levels or a much higher raw supply. Except when pushing over-large over-volted power tubes, there's hardly ever a reason to have signal over 10V. Any half-decent tube stage can do 10V at 5%THD with 100V, or 10V at 1%THD at 350V. 5% pure tube THD is hardly audible; if you expect point-something THD then you gotta use non-guitar hi-fi NFB schemes.
All stages after your Volume control, the signal level is at the designer's discretion. If you need 20V at the last stage to clip your power tubes, you don't care much what happens at higher levels: any softness is masked by power amp clipping.
The first stage, before any volume control, is not controlled by the designer but by the user. Normal guitar levels run 20mV to 500mV, and a 12AX7 will boost to maybe 25V. However a hard-plucked active bass through a booster pedal "could" ram 3V in, which should give 150V after the first stage, but will clip around 60V. Should the designer cater to "any" signal level"? (Even 70V PA outputs??!) Or is the user eXpecting "bad" things when over-plucking/boosting, and will be annoyed by lack of dirt?
Good 12AX7 git-amp design can use 300V-400V for the final driver, 300V-350V for the input stage, quite a lot less in most other stages, but extra-clean for input, volume-, tone-, and reverb-recovery.
Motorboating.... first leave out all the filter caps. All stages inject signal into the rail. Usually the last stage has the largest signal and does the most injecting. The rail signal leaks into earlier stages, is amplified, and encourages the last stage to inject more.

V3 has gain of 50 across 100K ohms. Without a rail cap and with a 10K dropper from the raw supply, about 1/10th of that appears across the 10K.
That signal sneaks via R2 back into V3, mildly attenuated by V2's plate resistance. However V3 inverts so the sneakback is NEGative feedback. Without some major complication, this is always stable. TIP: put your stages in pairs.
That signal also sneaks via R1 into V2 into V3, mildly attenuated by V1's and V2's plate resistances. Neglecting the loss at V1, we have gain of 50 * 5 or 250. And the inverter-inverter path is POSITIVE feedback. This is UNstable.
We must break the power rail, perhaps at "X", and insert enough signal-sneak loss to eliminate the forward gain throuh V2 and V3.
If all stages were DC-coupled, we'd be in a bind. To get 250:1 loss all the way to DC, we'd end up about 1 Volt. DC amplifiers do other things.
We are Audio men. The world stops at 20Hz and we don't pay to go lower. Therefore if "X" has 250:1 loss at-and-above 20Hz, we will be stable.
Actually the PSRR at V1 may be 3:1. So "X" only needs about 100:1 reduction at 20Hz.
And the full V1 V2 V3 string has main-path gain of maybe 50*50*50= 125,000 !! We will NEVER run three sequential stages wide-open! We have three stages because we have tone-control loss, mixer loss, cliper/filter loss, etc. If there's 10:1 tone-stack loss between V2 and V3, we only need ~~10:1 loss in "X".
I said we audio-guys stop at 20Hz. In fact we swing many ways. Guitar sound may "want" 70Hz or even 100Hz drop-off. Doing this with undersized coupling caps saves pennies. That also means less power-rail filtering which saves more pennies. OTOH, a cascade of many "20Hz" cut-offs adds-up to serious loss by 50Hz, so hi-fi systems often aim each stage below 1Hz. Also some tube coupling networks just don't cut-off much: a self-bias cathodyne has huge input impedance and the smallest (cheapest) cap may still pass to a few Hz. So there's some thought needed.