So He walks over and plugs in his 335, it sounded terrible
It's NOT just the humbucker pickup. I play humbuckers thru my TOS and Tweed BluezMeister both and the tone is very clear, IMO and it cuts thru a mix of our band really well. I don't think either amp sounds at all muddy. The overdrive is a very clear tone to my ears. Others have offered me similar feedback about the TOS, TBM and tone.
A few yrs ago, a Gibson semi-hollow body player came over and plugged into one of my amps. It didn't sound right. It was waaayy too dark thru one of my amps. However, I plugged my Tele with buckers in and it sounded super sweet & the player thought so also. This same guitarist used a Deluxe Reverb Re-issue and his amp and guitar were a good match for what he was doing.
The old Gibby amps were notoriously bright in some cases. HotBluePlates (who worked for Gibson) commented those amps were voiced bright because of how dark the Gibson guitars were.
I typically voice my amps to emphasize the mids more. Geezer seems to have somewhat brighter sounding amps than mine, perhaps?
Now I know Larry Carlton uses a 335 in a Dumble amp. However, my understanding is that he seldom uses the OD channel? I also heard that his OD channel had one instead of two gain stages? I don't know if either of those statements are fact or not? I will also say that LC's tone does sound muddy to me when his OD is cranked such as on the Renegade Gentleman and Fretwire CD's. I don't care for that tone. I strongly prefer his tone playing with the band FourPlay.
I do know from LC's website video that he intentionally sets his amp and guitar volume up to where the amp hangs right on that edge of breaking up.
The James tone stack on the OD section could be something of a factor? You might consider playing with the values in that (per Duncan Tone Stack Calculator or changing it out for a 5E3 type tone control.
Just my two cents worth. Best regards, Tubenit