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1750B.... its the largest SE OT I can find from hammond.125ESE is 15 Watts, and a big hunk of iron. 125GSE is 25 Watts.
1642SE is 75 Watts and
28 pounds.
Ah, I see.... you are just looking at their "Tube Guitar Amp" line. No, that won't go over 10 Watts because why would you build and sell a single-ended guitar amp that big? As soon as you need two power tubes, going push-pull allows an OT which is VERY much smaller (and cheaper) than a big SE OT, even counting the cost of a phase splitter.
So no mass-market money-making g-amp has ever featured much more than 10W in SE.
(Gibson did have a two-6V6 in SE, but not worked hard, so still probably only 10W; and i suspect they were using-up surplus chassis or discount OT from a collapsed radio product.)
The 125*SE series "is" guitar-amp quality. Not too bad, and not too good.
The '"Classic" - Single Ended' series is "too good" for guitar. The 125*SE series will go to about 75Hz at full power, the Classics are rated for 20Hz. Guitar only goes to 82Hz (or a few semitones lower), you don't need 20Hz (and do not want to pay for it or carry it). Guitar speakers aren't that good at 82Hz, you usually want some bass distortion to put bass overtones higher in the spectrum where the speaker will throw them.
If you want "the most" in a two-tube SE with 125GSE you need about 60 Watts worth of tubes. Five 6V6, two hot 6L6/EL34, or two 6550/KT88. And a huge PT.
One 6L6 or two 6V6 with a 10W OT is a more practical project.
If you just like HEAVY METAL, you can use the 1642SE ($321!!) at upwards of 150 Watts to get more guitar-type bass performance. You need 400 Watts worth of bottles suitable for 1400 Volts 0.28A.
Type 5-500A may be suitable.

Used 5-500As are available for $400.