On my recent build I solved a hum coming from the preamp section by isolating the input jack from the chassis and running it's own ground to the star grounding point. ... I was just curious if having to isolate the input is symptomatic of a grounding issue that could be resolved elsewhere in the amp?
Without knowing anything else about the amp build, I'd suspect a ground loop/fault somewhere else in the amp. Your post implies this was an AB763-type build, and whos knows how many thousands of those left Fender with input jacks electrically connected to the chassis.
If you used shielded cable, and grounded both ends of the shield, that would be a loop (though large-area loops usually cause hum were small-area loops like this typically don't).
Or if it's just good general practice? ... why is it necessary?
There is only one time I needed isolated jacks: building an amp which had a ground-lift switch.
The switch in that amp disconnects circuit ground from the chassis, while keeping the ground wire of the power cord always bolted to the chassis (to trip the breaker in the event of a live chassis). Inside the chassis, every ground was connected to a ground buss isolated from the chassis, so that the switch was the single point of connection.
The lifted ground in that amp results in hum if it is the only grounded electrical device in use; it breaks a ground loop and kills hum if I'm playing through multiple amps/effects which each have their own grounded 3-wire cord.
And yes, there are other ways to eliminate ground loops in multiple-amp setups if you don't have a proper ground-lift on the amps/effects.