I'm definitely going to lay the tubes out in a way that I can keep leads as short as possible. Should I nix the shielded cable on the grids of stages after the CC or should I stick with it?
Maybe, maybe not.
When you say 'as short as possible', 1 mans ceiling is another mans floor. As possible might mean, because of the layout, ~6"/7"/plus inches and it can depend on what those grid wires are close too, ie, hi voltage/hi current wires and transformers. So it depends on the amps circuit, your layout, the chassis size and type (mild steel is a better shield than alum.), ect.
Some (most) guys go with shielded cable for any/all
long grid runs, some start with just the input jacks, TS grid wires and the power tube grid wires (another would be the reverb recovery stage grid wires), then go from there adding shielded cable
if they encounter problems.
Another thing is the tone stack. After the tone stack caps, which are used as the coupling caps in most amps for the TS recovery gain stage, all those wires going to the tone controls and then to the recovery stage grid are grid wires. So to shorten up these wires some guys mount the TS caps (and TS slope R) directly on the tone controls.
They still use shielded cable going back from the TS to the recovery stage.
AND you don't need to use shielded cable for the short little wire runs between the TS caps.
The questions your asking are great but I think it would help you greatly to
look at Doug's and Sluckey's builds to see what where they are using shielded cable. 'A picture says a 1000 words." I'm trying to say to add them to your studies. I've posted the links for Doug's and Sluckey's in the grounding thread and other threads.
Brad