Pulled off a new genius move

Working on a new 5E3 build. Powered on today but has horrible noise to it.
The 5Y3 wasn't coming on when I powered up for a voltage check. Figured out I had it installed one pin off. Had to rotate it counterclockwise to get it right. (By the way the labels on the JJ 6v6 line up with the key. This 5Y3 does not. Is it common for labels to not line up with the key?)
I've been going over the grounds, but this has got me thinking that maybe the problem is the filter caps. It's hard to hear the guitar over the noise. Could putting in the 5Y3 wrong have gotten them?
Other thoughts on possible noise:
*Wire rating? I used some solid 18 awg wire on the pre-amp tubes. The stranded wire on those small things scared me in terms of keeping things from arcing. But the insulation on the 18 awg was pretty thin. I added heat shrink to them. Maybe they still don't cut it for the voltage?
*I twisted some of the preamp tube leads that go to the board together. This was to clean up the space. When chop sticking around I found they really interact with each other, but don't seem to be making the big awful hum. Should I avoid twisting any of these lines coming off the pre-amp? Also thought about making some shielded cables for these spots.
*Any recommendations on wire? Not liking cloth for connecting to the tubes. But seems really hard to find colored wire rated to 600v and at 20 or 18awg.