I've done this several times. The
Why was usually due to chassis size constraints, and not wanting the controls on the floor.
Here's the last two I did. The one on the left is a 6G3 Deluxe with a 8" speaker, the one on the right is a 5E3 Deluxe with a 10" speaker. the small cabinets provided the constraint... or if you enjoy the industrial engineering aspects of amp-building, provided the
challenge!! :-)


These are quiet amps, but of course, they aren't as quiet as you'd get if everything is in a single chassis. All your standard rules-of-thumb and amp design practices you'd do to keep the amp noise-free apply here. star-grounding, filament wiring best-practices, keeping the signal line isolated with shielded cable and away from the 120V and the 6.3V (on the 5E3, the power switch is on the bottom, so I didn't have to run 120V to the top).
The pre-amp tubes are in the top, so B+, ground, heater supply, (plus 120V for the switched one) all had to be run from bottom to top.
Maybe not required, but I made chassis ground a separate connection, and ran an isolated circuit ground from bottom to top to maintain a star-grounding type scheme. I also put the preamp stage filter caps up top, as close to the plate resistors as possible.
I used an octal plug/socket and an umbilical wire bundle for everything but the signal, which I used an RCA jack. I've used molex style connectors too (like a Magnatone M-series).
Here's a design decision I made for the 6G3 build, that if I did it again, I'd do differently: the tremolo tube is up top, near the two control knobs. space was tight on the bottom chassis, and I had space to spare up top. (I should say, when you do this, you draw a line through a schematic and say "everything on this side goes in the top, everything else, goes in the bottom"). SO, I ended up putting the bias supply circuit in the top as well, and running some neg. "
raw" DC voltage up to the top, and the
controlled bias voltage to the bottom. This means that the bottom chassis cannot function without the top chassis connected. Not an optimal design. But it works.
I've got another one in the works right now, and probably 5 more cabinets in the garage that it might happen to someday....
What I would like to do is just move the controls ( vol, tone stack, input etc ) to a separate small chassis and mount that on the top inside of the amp cabinet and leave the iron and the guts and all tubes mounted in another chassis in the bottom of the amp cab. If I were to do this, do I need to take any special care with shielding with these long wires? Will just using shielded cables be enough?
Be aware of the capacitance of your shielded wire over distance, but for 2' runs, it is probably nothing to worry about.
If the input jacks are up top, then you'd run the shielded wire to the bottom pre-amp triode (you might stick grid-leak and grid-stopper in the bottom close to the gain stage, which would rule out the nice fender style input wiring tricks...), then after the coupling cap, you'd run shielded wire back up top to the tone/vol controls,, and again, signal back down... (All the up and down is why I stuck the pre-amp tubes up top on mine)