Yeah I noted that you said schematic in one and layout in the other...but the two were typically part of the same document. I'm hardly "Mr Experience" by I can't recall seeing a layout that attempted to closely conform to a schematic per se ...
Forget that you may see the two together for a moment.
A schematic is a document showing the logical arrangement of electronic components, with a focus on how parts are interconnected. It may bear no resemblance to the physical product.
A layout is a document showing the physical arrangement of electronic components, with a focus on spatial relationships between parts. It
may show interconnections well, or it may make connections difficult to trace.
Generally, one looks at the schematic to see how the circuit is arranged (especially to sort out probably malfunctioning parts), then one looks to the layout to find where in the chassis the suspect part can be found. Sams went to the Nth-degree with layouts in one sense by using an actual photo of the chassis.
When Sluckey says don't compare layouts, he means tracing one to the other is needlessly hard. But if you had paper copies of the Hoffman layout and Fender schematic, and use a colored marker to check parts off, you'll find they're all there.