Being a blues player I am familiar with harp players and no 2 want the same amp.
But there are standard things about the amp. One is low gain and saggy power supply's. Feedback is a huge issue. You have to rethink things and forget about what a guitar does. This is a microphone with a different impedance and when the player blows harder and bends notes it does jack up the output a lot.
Also many harp player use a different mic depending on the room. Some use only one mic......like I said everybody's different. The key is low gain and being able to control the feedback without losing power and still being able to get distortion. Remember those old amps having mic inputs, even accordion inputs.
I would suggest a few different inputs tailored to his microphones, maybe using their own preamp triode. Also stay away from high gain tubes like the 12AX7, maybe go with the big bottle 6SL7 and 6SN7 tubes to get a fatter sound with less gain. Also many harpies like mixed speakers like 2x8' and a 12". I know they do like those old alnico 8" Heppner speakers, they have a lot of mids, much more then a C8R, I know I have a bunch of them both. Maybe a 40-50 watt amp with 2x10 and a 15 using alnico lower sensitivity speakers like a pair of P10Qs and a C15N type??????
Big iron, low voltage(paralleled 5Y3s???), big bottles, a lot of sag yet a lot of preamp filtering and low gain with some ability to dial out feedback(some type of NFB/resonance control).....a tall order indeed but it can and has been done.