This will be a little long, apologies in advance, but I hope to address all your questions:
1. I think that you are on the right tracks with the head + cab idea + the pre-punched chassis.
2. Please consider the 5E3 one more time before you commit to the Bluesmeister. The 5E3 has the advantage of being incredibly well documented and discussed, plus being a great classic amp. I have just built a Silvertone circuit that is very close to it and love it to bits.
3. However, kits: watch out, some are just the parts, no manual to speak of, often no back-up either.
4. 18 months ago I was in your position, but without the electrical experience. My reason to build an amp was to find out how they work, so that I could service the old ones that I have already. I just could not find a decent tech out here. My reasoning was that for the cost of a kit I could get a pretty good grounding. It ended up to be a champ kit. With that grounding, I tried to build my dream amp from scratch in a pre-punched chassis and just a circuit diagram. Let's call it the Fartmeister. After six months fiddling I tore the thing down because I could not find out why it did not perform. But, while trying to get it to work I learnt a bunch.
5. I am a little concerned by you jumping straight in because my Fartmeister was about the same level of complexity as the Bluesmeister.
6. Tubenit and Geezer make a hell of a lot of exciting amps and I have real trouble keeping up with just reading about them! The documentation is prolific, but it assumes a certain level of knowledge of tube amps that you may not yet have. Now after 18 months, 1 kit, 3 scratch builds and 5 tube-amp repairs I am really itching to tackle a Geezer / Tubenit amp and I can really understand your entusiasm. With enough research on your part you may manage it.
7. This will seem completely wacko, but it's me: Try to get both the schematic and layout, cross check it all yourself before ordering the parts. Get colored pens and trace over the layout and schematic in the colors of your choice. I do that about 5 times. Think about why it was done that way. Again, about 5 times. Think about what you want. Hopefully less than 5 times! Then I order the parts when I can trace the whole circuit in my minds eye before going to sleep.
8. Tino Zottola has two "books" that possibly fit your level of expertise, but he does not have the Bluesmeister circuit in there! Plus, you would have to cut the metal holes yourself... One book is on theory, the other walks through several builds. You would need both books, otherwise you will be "painting by numbers" and not get much level of understanding. The builds are real nice old Fender circuits but again assume that you can read schematics and that you are comfortable working with high voltage. The layouts are all drawn in several stages of wiring which may help address your wiring questions.
9. Wiring: in a nutshell, keep the signal wires short and away from the high voltage / current wires and get the grounding right. Research all that.
10. If the budget is real tight I have to warn you that doing this kind of thing can get addictive.
my fingers feel numb... I have to get back to the cave, smell some solder, drill some holes...