Depending on playing style ofcourse losing too much high end frequencies can quickly help make an amp sound dull and suck the real tone, life, and soul out of the guitar, so one must be very careful here. It'd be a shame when so much care, thought, & money is made while selecting tone woods, pickups, strings, speakers, tubes, etc. and it's all being colored or muffled and can hardly be distinguished or heard clearly the way it should be. When an amp is properly fine tuned and the mark has been hit, it plays equally well and clear w/ single coils of Strats and Teles to the humbuckers of a Les Paul or semi-hollow body. And the same with whatever speaker & cab is being used meaning it sounds the way that instrument or speaker is supposed to sound like and you know it when you feel it resonate in your hands and sustain in your finger tips. This is just MY definition of "perfect".
A similar analogy of sound waves through air is the sun's energy, intensity and light spectrum as it penetrates the ocean. The first parts of the light spectrum to go is the the red, yellow, and orange. This represents audio highs to mids. Within the first five meters the red begins to be filtered away, w/in 15 the yellow, and so on until only the blue is left which can go much further, up to 150 meters the same way the lowest bass frequencies can travel and be heard so far away. Sound waves are the same. The uppermost, sunlit layer of the ocean is where 70 percent of the entire amount of photosynthesis in the world takes place and is called the euphotic zone. This upper region so abundant with life is the place to strive to explore and appreciate the true character and fine nuances of the tonal spectrum, careful not to get too close and fall into the muddy, dark, and undefined lower depths of the aphotic zone. :)