"constipated" is another one of those subjective words that mean any number of things to different people but...you are right in that there's more bass thoughout the entire preamp which can have detrimental negative effects to tone, sustain, oscillations, etc. Bass is the primary frequency range responsible for blocking distortion. Even in minimal amounts it can have an effect of muddying up your tone very quickly and when muddiness is compounded and reamplified it can get even uglier in a hurry. As Merlin & Aiken suggest, each gain stage can be manipulated to increase hi & low frequencies from what the input signal contained just as you can reduce these frequencies too. The trick or better to say 'task' on designing multiple gain stages is to find the right balance through each gain stage to the other and amplify the 'right' frequencies AND in the correct way too. Simply changing coupling caps or tone stack values isn't really enough because knowing how to utilize your load line w/ voltage, load resistors, cathode resistors, bypass caps, smoothing caps, feedback loops, etc. all come into play here along with the coupling caps. This being said, subbing a .02mF w/ a .002mF early in the first one or two gain stages can make a very nice improvement w/out making things overly complicated. For me it's got to where my first gain stage (or two) can easily use a 2k2 w/ 2.2uF for the cathode to also go along w/ the .002uF coupling cap afterwards where it works and sounds beautifully going forward.