> I am comfortable with the High power and High Voltages.
It's not (just) that.
In tubes, a failure here won't (usually) cause a smoke-producing failure over there. The DC conditions are per-stage, isolated by caps. (In tubes or transistors, audio failures don't usually cause smoke.)
However in the classic audio Power amplifier, each stage depends on the next. In your plan, if Q1 burned open, the output would slam to the negative rail, 50V across the speaker, and loud buzz or burnt speaker. Open Q2 slams the other way with equally unhappy result.
Further there are domino failures. If Q8 fails but open, Q6 will try to drive the speaker. If this does not cause lousy sound, Q6 soon melts.
If both Q8 and Q6 have failed short, but you only find and fix Q8, the shorted Q6 will slam Q8 and probably melt it again.
In more complicated amps R10 R11 are another transistor, loading/fighting Q3. Now you can get into multiple failures where if you fix 2 out of 3, other good parts melt.
Which is why I outlined all the way to the basic low-power amp, Q1 Q2 Q3. All the rest just buffers from the 10K that Q3 can drive down to the 4 ohm load. If you cut back to here and get Q3 to force Q2 to match Q1 bias (0V), then you can build-back the output sections, pair at a time, with no load, and possibly with huge (100X) emitter resistors to delay burn-up while you poke.
Can you tell I've had way too much fun with these things?