I think it would be a lot of trouble. Probably a pretty thick steel chassis, very tight, very unforgiving of parts placement different than the original, probably VERY hard to find a place to mount a power transformer. Reminds me of my CONN organ chassis.

Gee, I look at that and lo and behold, there's a nice big power tranny, an output tranny, octal sockets for output tubes, even some tube clamps. 9-pin wafer sockets (that I would replace, but the right-sized holes are there. But if you study it for a while, you'll (maybe, maybe not) come to the conclusion that there's no good place (on either long side of the chassis) to put the controls that is not interfered with by the power tubes or the output tranny and we'd like to avoid that. There's definitely no good place to put a parts board so it would almost have to be point-to-point, which is OK I guess, but not my preference. Here you have this nice long chassis but the power supply is cramped really close to the preamp section. Assume you move the power supply caps (whether can-type or piled-up Fender type) to the other side of the power trans, the power supply still takes up about half the chassis footprint, and even if I got the p/s caps out of the way, the space they would vacate is not exactly where I would want to place additional preamp components. So now what, move the power transformer? Make a plug to fill up the hole that would leave? Just let me know when you think you'd have to do more metalwork than any sane man would do.
And thanks again, by the way, to the folks on this forum who pointed out all the negatives with re-using this chassis when I brought it up some months ago. I am sure it could be done, but I'm also clear the results would not be that great, and there could be some truly annoying hum issues with the "novel" layout.