Possible script: client sets-up, forgets to connect speaker, hears nothing, turns up and beats the strings "to get something". Extreme signal with no load kicks-up HIGH voltage in the OT. Paper insulation breaks-down. Winding shorts to core which is grounded. Now the PT and rectifier feels a dead short to ground, something burns-up.
Enter Quatro.
You apply load, replace dead rectifier, get arcing inside OT. Unless you peek inside and find a cockroach carcass, NO actual damage, then the logical assumption is that the OT is arced to death. It "could" be re-wound, but custom labor and both-ways shipping of heavy iron usually makes a new mass-produced OT the better option.
With new OT installed, bring it up without power tubes, with a load, with a meter on the B+, and preferably a 45 Watt lamp-limiter. It should come up without drama, and with a somewhat-high B+. Put in one output tube, should be no drama, hair-high B+, and it should "play" though not in full glory. Try the other output tube. Try it all together and beat it for a while LOUD and soft.
See if it is possible to fail-safe the load connection. You don't mention make/model, but any cathode-biased tube amp can be shorted without problem. A shorting jack protects against empty amp-jack. Nothing really protects against the other end laying on the floor behind the speaker. You could add a permanent load resistor. Perhaps 5X the resistance of the tap it connects to at 1/5 the amp's rated power.