>Plan to be wrong about something.
At the very least.
I built a proto using a very, very cool idea. This idea was to make it as modular on the inside as possible - separate boards for each preamp channel, power amp, effects loop, etc. The really, really cool part was that the two preamp boards would be stacked and - you getting this? - the top one would be hinged and flip up to expose the bottom one! Did I mention how incredibly cool this idea was? Trouble is, once I got everything nailed inside, I couldn't wire it in any configuration that would allow the top board to flip up. I couldn't get to the bottom board at all - and I realized as the proto process developed after it was running that I needed to change component values. Crap!
To make matters worse, I had also decided to flip my pots upside down. This would allow me to run the hookups along the bottom (top) of the chassis and give me room to flip the board up. This obviously turned out to be moot since I couldn't flip the board up anyway AND Murphy the anti-amp tech was around to make darn sure I had a few problems with those pots as well that needed fixing. Of course,I couldn't get to them now because the preamp boards were too close and their freakin' upside down! Grrr!!!! Double crap!!
Solution? Rip the stinkin' boards and pots out and redo the whole thing. I've still got stacked boards in there, but I'm slaving feverishly to use as much of Doug's style of layout style as possible to cram everything that was a problem this time onto one board next time.
If yours will be an untried, untested, unproven layout, absolutely expect failure once or a few times. Note that my problems were nearly all mechanical ones and not signal, but I only got lucky on that. The best laid plans of mice and amp designers often go astray.
If you can use one of Doug's layouts, even if you have to mod it a little to fit your design, you'll be miles ahead. And you can score his board building stuff to make it easy to build others like it. I sometimes feel guilty about taking so much advantage of someone else's hard work, but I'm finding ways to get over it.