I have built all the amps I want to play and on every build I have a loop that will allow me to use only the Power Amp section. Now I build preamps to patch into any of the amps I have built. So much cheaper to build a preamp, which IMO where the basis tone is. Most I tire of quickly, but my building of amps got really out of hand to the point where the amps began owning me. I sold all but 6 of my builds. I still do not want to admit how many tube radios and amps I still have and I still bought a Philco am last weekend.
What is cool about doing what you are considering is if you take your time and consider building a Tube Power amp that has enough current to run large tubes, but low enough voltage to run all octals. Make it with a switching rectifier from SS to tube and you can achieve a multitude of different voltages.
Tubenit like to build with 330-0-330 I think. Maybe he will see this and chime in on all the different voltages he gets simply by changing rectifier tubes.
Brian Wampler makes some very nice pedals, but if you do not run them into the front of a preamp tube you will hear diode switching more easily. If you can, put you overdrive pedals in a FX loop on a tube amp amp and play and listen. This will give you an idea of what you will have. Some folks pay no attention to diode switching, but I hear it and it drives me nuts. I don't notice it much at all in front of a preamp.
Don't take me the wrong way, I love all pedals simply because it is fun to me. I don't use a lot, but have quite a few. Also recording the output from a pedal and playing at amp volumes through a stereo will reveal some of this sound too.
Forum Member Jojokeo builds some really nice pedals as well. The FuzzShway he sent me if a blast and I am still finding new ways of using it. I'll bet if you PM him he will have some great insight on using a pedal as a preamp. Brian's pedals have active preamps and a really hot when turned up a little.