Sluckey & Ed have lots of experience, so their guessing could be pretty close. If you know your amp is similar to a published schematic, you can check that. If you're facing utter mystery, Ohm's Law is your friend. V = R x I. The Voltage Drop across a resistor = Resistance in Ohms x Current in Amps.
Check the tube spec charts to find the current draw for the tubes in your amp. For power tubes both the Plates and Screens draw current. For preamp tubes you can simply assume at first that they each draw 1mA = .001 Amps. Add up all the current draw downstream from your B+ resistor. Determine what voltage you want on the downstream side of the resistor. If you have 350VDC on the upstream side of the resistor, and want 300VDC on the downstream side, the Voltage Drop = 50.
So, Vdrop = R x I; 50 = R x I; R = 50/I
If there are 3 preamp tubes downstream from the resistor, then I = .003; 50/.003 = about 17K Ohms.
If you wind up with, say, 280VDC instead of your target of 300: You now have enough info to calculate the exact current draw given the actual Voltage Drop of 70. Then recalculate Ohm's Law for the exact R value. No guesswork is required (except for the standard, tentaive guesstimate of preamp current draw).