Here's some good reading to support your thirst for knowledge:
Microsoft Word - Fundamentals.doc (valvewizard.co.uk)I just don't have any experience as to how that translates tone wise in relation to gain, headroom, etc....
Think of headroom as the ability of a stage to pass the largest signal possible before clipping. Anything other than that would be less headroom.
For headroom, you would want a high anode voltage combined with a center bias point. This would be a great way to have a nice clean tone.
If I were you, I would change my definition and usage of the term "gain" to reflect it's actual meaning = voltage gain. (not distortion)
When you start to blur the terms you are inviting in opinion to interfere with the facts of voltage gain.
I say this because I respect that you are really trying to learn.
IMHO your 2 scenarios alone create a negligible difference that depends a lot on your anode voltage. A single gain stage is made up of 5 or more negligible differences.
TONE comes from the way you alter the frequency response from stage to stage. Bypass caps, coupling caps, tone stacks, etc.
One factor to consider is that the "Marshally" version has an un-bypassed 820r, so that plays into the TONE of that stage more than the actual bias point.