Are you saying by lowering the grid stoppers to 10K it will significantly reduce the load on the guitar pickup.
No, It significantly increases the load if you use the lo jack input. Load was probably not a good word in that a high load (more current demand) is like a low input impedance (low resistance). In this case when plugging into the lo jack on a bassman the input impedance would be about 136k ohms, if using 10k grid stoppers instead of using the standard 68k the input impedance would be about 20k, so there would be more current demand from the pickup, a higher load.
One reason for using grid stoppers is to create a low pass filter with the miller capacitance of the tube. On the input of the amp, the low pass filter, filters out frequency's higher than the audible range, greater than 20k Hz. The 68k grid stopper and miller capacitance of a 12ax7 (about 100pf) creates the low pass filter. If you reduce the grid stopper to have you need to increase the capacitance to keep the low pass cutoff at 20k Hz, so the effect on the highs would be the same. If you have Merlin's book look at page 87.
You should experiment with different resistor types, as well as capacitors, tubes, etc. I've found that recording the amp then changing the components and recording again is the best way to compare, if you can do it blind it is even better.