As a rule of thumb guide for layout, any wires that carry highish current or highish voltage AC (such as heater wires or leads/wires connected directly to tube plates) want to be about 1" away from any signal wires, or if these cross signal wires, they should cross each other at right angles. AC pairs (like heater wires) can be situated (or twisted) close together so that EMF between them gets cancelled out. Some people do this differently and claim success at avoiding unwanted sources of interference.
Obviously tube grid and plate pins are closer than an inch to each other, but tubes are designed to function this way. However, in principle you should try and avoid creating a layout which results in more AC parallel wire runs between plate and grid wires that results in unwanted electromagnetic induction (which can cause crosstalk, oscillation etc).
Classic Fender amp layouts have the tube sockets on one side of the eyelet board and all the signal switches, pots, input jacks, etc on the other side, and lead dress that kinda follows this principle. Some newer amp designs break this 'rule', but even in these designs, good layouts ought to follow the same principle IMHO. Not saying you might get away with something different, as it also depends on how noise-sensitive the signal is in your FX loop. Rather, its just something to think about when you're putting your FX loop level pots at the back of your amp chassis next to the tube sockets. YMMV