This has been making my head explode. I think the technology is closer to the hi-fi world than guitar amps (except for the input impedance). So I think you have to work backwards, starting with speaker (driver) selection. I.e., I think speaker selection is critical.
For the tweeter: Your upper frequency is, say, 10,000Hz to cover extended guitar string harmonics. To avoid distortion, you need a tweeter that can cover up to 12,000 -15,000Hz, to avoid maxing it out.
Then, how low can the tweeter comfortably go? That's your crossover point with the main speaker. The main speaker needs to comfortably cover from say 80Hz up to the crossover point.
Now , back to the input. You need a hi-impedance input as discussed in this or your companion thread. Re the acoustic guitar PU: the input gain stage will act as a buffer / voltage amplifier. Now you have choices:
1. Use an effects loop out or line out from the main amp > outboard active crossover such as a Behringer rack unit which will split the signal for the tweeter, and for the main speaker.
Lo Freq feed from active crossover unit > Effects Loop/Line In on main amp > main speaker
Hi Freq feed > SE amp > tweeter
2. Split the signal internally in the main amp after the input stage:
One half goes downstream in the main amp > internal lo-pass filter > power amp section > main speaker
Other half to Line Out > SE amp with internal hi-pass filter > power amp section > tweeter