I think it is doable
Consider an amp where you have two separated preamp channels that are mixed at the PI or mixed before to go to the PI
then you have the PI that feeds two output tubes (one for each branch of the PI) the plates of those tubes are connected to the primary of a PP OT and the secondary of the OT to a Speaker
well, consider that in the past happened that missing PP OT some brand (italian for sure - See attached schematic of the Corland HiFi Guitar Amp) buid the power section using a pair of SE OT instead of a single PP OT
So build a power section with two SE OT that feed each one on a speaker (so you have two speakers but mono signal)
you have
Two input >> Two preamp channels >> MIX (resistors or MIX at the PI) >> PI >> Two Power Tubes (working in PP) >> Two SE OT >> Two Speakers
with this configuration the Preamp are mixed and via the PI feed the Two Power Tubes that acts in PP (also if the OT isn't a PP OT but are Two SE OT)
this way you miss the noise cancellation due to the PP Transformer windings but has anyway a PP Power Section
Then you can bypass the MIX circuit (if done with resistors as an example) and bypass te PI
you must bypass it in a way each Preamp Channel feeds the input of one power tube and you are done
Franco
p.s.: On the Corland the secondary of the two SE OT was connected to a single speaker but you can connect each secondary of each SE OT to a dedicated Speaker, so you can perform Stereo function if you bypass the MIX and the PI
The first approach to the amp that has two SE OT and acts in PP
The first Schematic of the amp as it was original
The redrawn schematic with the two original SE OT