ALL ATX computer systems will have power running to the motherboard, even when seemingly off. If your power switch is connected to the motherboard instead of directly to the power supply, it is ATX, and ATX has been sold for about a decade or so now. The old AT type stuff would be a [80]286 CPU (Well, connectivity wise, even back to the original IBM PC and it's 8088) to a [80]486 and to a degree, the Pentium processors. (That's the time period that the switch from AT to ATX started taking place.)
It's possible even for the best power supplies to act flaky if they go bad. A good brand just means it shouldn't go bad for a LONG time (it does and can happen, not as often as the el-cheapo power supplies though. AND those el-cheapos can have a bear of a time even coming close to rated power output.)
It's more likely a problem in the sound card though as the rest of the computer seems to operate fine. If you stick in another one (sound card), or enable and hook up and built in audio card functions, and it goes away, I'd blame it on the sound card. I've got an Audigy card here (not on my new build here though) that it doesn't matter what drivers (original, or the newer ones that support OpenAL) the volume will have a tendency to change on me every so often.