I still use some of those for AM transmitter toys I play with, in particular the 117L7 and 117M7. I'm pretty sure PRR turned me onto them. On some the early ones I built, I used an iso transformer for everything but the heaters - mainly because of the transformers I bought. I didn't worry too much about it in that application, though, since a transmitter isn't something you want to be sticking your tongue to anyway if you can help it.
The 117-types I play with don't have a lot of horsepower for audio amp work and there are better/safer tubes available for low power applications. Still, if you happen to have one or two, it would make a nice test project. Be sure and use a PT that will allow you to isolate everything... or at least test it with a 117V isolated mains source if it turns out to be bench-play only.
If you do try one out, pay close attention to the internal structure of the tube in question. The two tubes I mention above that I use also have two more siblings in the series with significantly different internal connections, but nearly the same numbers (i.e. 117P7). You can't isolate individual source voltages with those two and they might not be interchangeable, depending on the circuit you use. FWIW...