[long winded version of JJ's post]
In my limited experience, there are two keys to unravelling this Gordian Knot and they are inter-related:
A) Figure out which individuals and/or resources
usually are reliable sources of information (as opposed to unsupported opinion), and
B) Test things yourself
It's really an iterative process where you develop reasonable filters, apply advice or "facts" to a real amp, revise your filters, ad naseum. After a couple of builds and a couple of years, you'll identify certain information sources that you can trust implicitly. Others may be mostly fact, but sprinkle opinions in which frequently are presented exactly the same way as "facts". For me, Randall Aiken, R.G. Keen and our peerless host Doug Hoffman fall into the first group. Merlin and the Tone Lizard fall into the second group. Kevin O'Connor straddles the two - mostly really solid facts but there's a sprinkling of opinions stated as facts which are hard for the novice to identify as opinions. Of course, there's also a third group you have to identify and largely ignore. Harmony Central???
Another thing to keep in mind is that even well intentioned folks who are reasonably knowledgeable may not be able to answer your question accurately. They don't know all of the things you've already tried, and they don't have your amp on the bench to look at, test, tweak, etc.
Also, "great tone" to my ears may be like fingernails on a chalkboard to your ears. "Anemic" reverb for one guy might be "swampy" to another. Neither one is wrong, just different perspectives. I was all set to build the "Single Ended Lead" design on AX84 based on all of the positive comments on its great tone. Even bought the transformers (yes, I am a moron at least some of the time). Then I finally found some sound clips. Modern high-gain metal or whatever you call it is not my cup of tea. Back to the drawing board to figure out what to do with the transformers...
Going to original source documents helped me a lot. Examples are Jack Darr's book, The Radio Designer's Handbook, tube data sheets (search function on Pete Millet's site), etc. Actually, Pete Millet provides a great collection of original material:
http://www.tubebooks.org/technical_books_online.htmDoug's Library and Schematic Heaven are invaluable resources IMHO. Sure, you can pull up 100 variations of the "18 Watt" Marshall, but why not start by looking at the original? PRR keeps reminding me that there's no substitute for "known good" schematics and layouts. Of course, I keep ignoring that concept to a greater or lesser extent.
I've tried to put together a fairly comprehensive set of links in the "References" sticky. I add references as I stumble on new ones, but frankly I wish other people would give me more input. There's no way I have read half, let alone all, of the stuff in those links. Plus, sometimes links go dead and I won't know it unless I try to go there myself. That's a bit off-topic, but a plea for help anyway

One last thought: there's no substitute for building the same amp twice. Seriously. I built, and then re-built a 5F2-A derivative. Learned more from the two re-builds than I did from the first try. I built two Princeton Reverb clones and learned at least as much from the second one as I did from the first. Following up with a Super Reverb clone helped even more. Now I know how to build a moderate gain amp with reverb and bias vary tremolo. IMHO that's a reasonably solid foundation.
Good luck!
Chip