Rather than posting my own ideas on this one I'd rather post something from someone that's respected but is also MIA or I'd ask him. But, since it's already in the public domain it should be okay anyway. I liked most of what I read as I've done or agree on many of the same things.
Here's part 1:
My builds look like rat's nests inside, but are silent as death... like all the old HI-FI gear that was even messier, and even quieter. Radiated fields will kill you... squeals galore. Shielded wire will help, but it is not a cure all. Everything is exacerbated with higher gains and more stages, so you have to be much more deliberate in your designs.
My tips...
+It starts with a good power supply: -Get the ripple out! I usually regulate, and then bypass the supply nodes close to the pins with a .1uF CERAMIC capacitor to shunt any noise picked up along the wire run to ground.
-Make sure your rectifier diodes are not radiating RF
-use fast, soft recovery diodes and snub them, or use a tube rectifier (I do in almost all mu builds now).
-In addition to regulating, use a CLC power supply stage first. Just do it. Capacitors' effectiveness decreases as the impedance increases... that's the ESR problem, but chokes are the opposite, so they compliment each other and work better across the board. They also by their nature, convert sine AC ripple to a more saw tooth shape from their ramping up/down action, so the regulator will more effectively cancel out the ripple.
-MIND YOUR CURRENT LOOPS! Don't use crappy multi-section can caps. Use separate capacitors, and place them near the stage that they are filtering and keep the wiring in the loop short. I use 1 cap per triode if they are opposite in phase, if you have two cascading sections that are the same in phase, then separate their supplies.
-Keep the AC input and rectifying part of the supply HELL AND GONE from the preamp circuit... all the way in the opposite corner of the chassis. Keep the loop around the first filter cap as short as possible so that it does not become a quarter-wave antenna.
+Filaments:
-Elevating AC filaments works really well for getting the ripple noise at a different potential than the cathode, so you are not shooting AC noise into your circuit, but you still have AC traveling around your circuit, which will radiate crap for your sensitive grid nodes to pick up. A better solution is to use a good REGULATED DC supply, with a choke filter and then also elevate it, AND use shielded twisted pair wiring. This is not necessary, but it will eliminate completely the chance of filament interference. BUT I must stress that it has to be a GOOD regulated supply, or else you will be only making things worse.
-Keep your filament wiring as short as possible, and use solid wire so that you can make all your bends at 90º angles... loops are RF antennas! So keep the bends sharp. Keep the filament circuit away from the other wiring. I always send the signal wires in on one side and the filaments on the other. I also use 12v filaments so that I can only have to approach the tube socket from one side, rather than wrapping around to the other side to hook up to pin #9... and as a bonus, you'll need less current. And lay the filaments against the chassis for extra shielding. -Even with DC filaments, bypass each tube's filament to ground right on the tube pin with a .1uF CERAMIC capacitor to kill any picked up stray noise in the heater wiring.