If you face any humbucking pickup at a t.v., monitor or power transformer, it will pick up a buzzy hum. The closer you get, the louder the noise. The more gain your amp has, the louder the apparent buzz/hum. You will notice a hum when facing a particular way, and less/zero when turned about 90 degrees on an axis (or two).
So on a tube amp, a loop would cause far more problems because of the voltages?
No, ground loops are about currents flowing through the loops, and interacting with each other. This happens more readily when 2 points that should both be "ground" (or 0v) have slightly different voltages. This could happen when you make a large loop; one "0v" point might not be the same as another 0v point.
Big loops or wiring paths can also be bad within an amp, because they can act like an aerial or antenna. If the circuit is high impedance, and has a large loop hanging off a tube grid, you will likely pick up hum and/or oscillation. The coupling could take place due to radiated fields due to large a.c. current, or it could take place due to electrostatic induction due to large a.c. voltages.
I was thinking of removing wire 2 between the tone pots.Would that do anything at all?
I don't think so. Cut and see if you want. But most modern Gibson guitars are wired with all the pots on a sheet metal plate (a ground plane), but the grounds for the pickups are still made by soldering the braid shield to the back of the pots. Is that a ground loop? Yeah, probably, but no new Gibson guitars have ground loop issues.