I have done two variations of what you speak of. I modded a Princeton Reverb using Dynaco ST-35 power and output trannies, changing the tubes to 6L6. The PT went about where the original PT went, but the OT is all the way at the other end of the chassis. I ran the leads to the OT (HV and speaker) outside the chassis, because even back then (I did this over 30 years ago) as little as I knew, it made no sense to run those leads through the preamp section. Yes, I insulated the bloody hell out of them. Of course there was a wire splice 4-5" away from the OT on every lead. Those got tubing, plus I insulated almost all the rest of the wires with more tubing. It's been working for 30 years.
The second variation was to mod a Deluxe Reverb to 4 (yes 4) 6L6. Hey, we wanted watts back then, and a Deluxe Reverb was not a rare thing at all. This one, a Twin Reverb OT went in place of the original. It was ultimately necessary to remake the baffle board and carefully rotate the speaker so that the tallish OT poked down between spokes in the speaker. This used an Altec 417-8H which is a deep (NOT like a JBL D-120) speaker with four spokes. Goofy, but it worked. That one still works, too, though I have taken out 2x 6L6 and downgraded the OT. Still have the power transformer from 4 x 6L6 power which weighs a ton, but I just didn't want to mess with it.