I like the mdf wood, (even though heavy, my 212 cab is made out of it), it has a smooth surface, cheap easy to paint put a heavy coat of laquer on it with some bone corners, and its good enough for me, hehe
Fair enough if you like it.
Why are the 10uf electrolytic caps on that layout showing the positive end going to ground, is that right?
Bias filter caps; the output voltage is negative.
What if I condense this to an 18" chasis instead of 24" bringing everything closer together, move the power & preamp tubes next to the can caps, and push the choke and board back?
The big problem (to me) is swapping positions of the input jacks and power/standby switch.
That puts the Presence control next to the input jacks, begging for oscillation. That's because relatively big signals from the speaker/feedback loop are right next to low level, high impedance grid wires for your first gain stage.
Also, you have most things on the chassis (tubes, jacks/switches, big part locations) in a mirror-image, but you didn't flip the board or the controls. Like Sluckey said, you'll build it and then wonder why you're having weird stability problems, buzzing or distortion on weak signals (if not outright howling). You're also having to run high voltage a.c. past all your controls to get to the bias circuit on the input side of the chassis, which will probably result in a hum you won't get rid of until you move the bias circuit back over near the PT and keep a.c. wiring away from the controls.
I STRONGLY encourage you to copy the known working plan. Did you just need input jacks on the right side of the amp instead of the left? Keep in mind that Marshall amps, when built with tubes hanging down in a combo like a Fender amp, have the input jacks on the left side just like a Fender.