Kevin O'Connor's TUT books have several sections scattered in different volumes on dc stand-offs, dc heaters, regulated dc heaters and dc heaters
with a dc stand-off.

He's very clear in them that he finds a noise reduction (up to 30dB) with dc-elevated heaters that's well worth the few parts and space it takes to do this in a new build. Now he does have a lot of hi-gain amps in his books that might benefit from this more than a more standard gain amp.
This is an old idea that has been used for decades on different production amps and Hi-Fi stereos. As Sluckey pointed out 1 way to do this was they would tap a dcv from the power tube cathodes on cathodes bias amps. Look at old Ampeg amp schemos.
Kevin's books list 70 to 80 dcv for the stand-off, most guys here that I've seen use a dc stand-off are using 30 to 40 dcv and report very good results. (Kevin doesn't think you get the full noise reduction that you could get using ~75dcv.) On my 5E3, 5G9 and stand alone reverb I used ~75 and I think their very quite. (Now I also did use KOC's grounding too. It's a wired grounding scheme with all jacks isolated/insulated from the chassis and only 2 chassis ground connections, 1 for the circuit ground, the other is the power cord 3rd wire safety ground.)
As far as dc stand-off versus dc heaters, IIRC Kevin has said a number of times that a dc stand-off can be as effective or better than dc heaters. Merlin has said if dc heaters are not done correctly they will actually be noisier than ac heaters. He explains himself but I forget what he wrote.
I can't find it right now but I remember Kevin recommending going the distance by using dc heaters with a dc stand-off for things like mic pre's or any other
very low signal circuits where any extra noise reduction would be desired.
Kevin and others (Power Scaling forum) have said many times they believe
regulated dc heaters are unnecessary as they are overkill and offer no audible difference than just going with a dc heater with dc stand-off.
Now if you had a proto bread board (like Pete, Richard, SG and others here and I think Pete and Richard have done some hands on tests.

) along with a scope and maybe a few other pieces of tech test gear you could prove it on a micro level, but......

To me, bottom line, best bang for the buck, considering what I've read, have heard here, have experienced in my few builds using it, cost of parts, chassis space and wiring time versus noise reduction in a guitar/musical instrument amp?
I'm sticking with a simple dc stand-off but at ~75dcv.
What John said is true about saving a modern production 12 _ _ 7 tube from shorting out from being used as a CF because of high voltage between the K and filament. A number of guys have had that problem and posted about it here.
I also still want to try adding the hum-dinger pot that John brought up with the dc stand-off. It may well be worth the extra pot and hole in the chassis.
Brad