As I understand it, the FX design I use has a CF in the 1st gain section. Could a mosfet be substituted there and not mess with the tone. Think that would work?
Sure.
But why do you still have the 1MΩ (grid reference) resistor and the 1.8kΩ (cathode bias) resistor? Now that you're not using a tube, it seems neither of these are needed. Or at least they weren't needed in your other source follower stage.
My impression is that the CF/send of the FX had little to no gain factor to it? And I was thinking that "IF" that is the case, then maybe it is redundant?
Why did you need the cathode follower in the circuit as it is now? Did it do anything over not having it? [Hint: you could probably connect that 0.05uF going into the cathode follower grid to the top of the 100kΩ Send pot to find out]
None of the cathode followers you've used have any gain to them (in fact, a slight loss), but they've all done something to your circuit, right?
So gain wasn't the feature. Instead, cathode followers can buffer one circuit from another. Tone stack causes loss with your high impedance plate output? Stick a cathode follower between them to give a high-impedance load to the gain stage, and a relatively low source impedance to the tone stack.
In your case, you're coming out of the tone stack, going to a 1MΩ level pot, then you also need a 100kΩ Send level pot leading to your effects. A follower between the pot buffers the channel level from the send level (to minimize interactions), and helps restore a lower driving impedance that would be wrecked by the 1MΩ pot.
Remember that the cabling between the amp and effects will have capacitance, and the effects could have a somewhat low input impedance. Both of those will knock down treble and/or overall signal strength, and the effect could vary with a changing setting of a pot (especially if you have the 1MΩ channel level directly feeding the effects).
Regardless, it shouldn't be too hard to test for yourself (by simply omitting the existing tube cathode follower). How bad any impact might be varies with the characteristics of the specific effects used, as well as the length and quality of cabling between amp and effects.