... 400 volt b+ with a total distortion of 1.1%. Am I correct assuming that at v1 this would result in less preamp dirt?
When you play through a professionally-designed and commercially-produced amp, the first thing to distort will be the output tubes. To do otherwise would educe the amp's clean output power and make the amp seem "weaker".
The exception to this is a master volume amp, in which case when the master volume is set low, the gain stage immediately before the master volume is the first to distort.
The 1st gain stage will almost never distort noticeably unless you're playing a CD player through a guitar amp (which has an average signal level 10 times as big). Unless you cannot get a clean signal for any setting of amp volume controls and have to resort to turning down your signal at the guitar/pedals, then distortion in V1 is likely not your issue.
So then a general rule for a clean preamp might be to make sure successive gain stages can handle bigger and bigger input signals, that way as the signal is amplified through the circuit, no gain stage distorts. The cleanest tube amp I've heard (a Standel 25L15) uses a 12AX7-12AT7-12AU7 preamp, in part because each successive gain stage can handle a bigger input signal before overloading so the signal stays clean throughout the amp.
400 volt b+ with a total distortion of 1.1%. Am I correct assuming that at v1 this would result in less preamp dirt?
Back to your original question. A higher supply voltage
could allow the stage to make a bigger clean output signal. But the tube has to be biased appropriately; if you took a tube at any supply voltage and biased it at saturation or cutoff, it would be impossible to get anything other than a distorted output signal.
Desired input & output signal level, desired function and tube type are also factors that would impact how you would set up a gain stage.
You should know now that amp designers
do not typically design from input stage towads the output; they start at the output stage and work backward towards the input, given a knowledge of what characteristics are needed from the output stage and the characteristics of the input signal going into the front of the amp.
... could v1a be cascaded into v1b via a switch for a "dirty channel/gain boost"type of thing?
Yes. But with no other work, it would sound the same as simply turning the volume control from 5 to 10. In other words, you'd get a lot more volume along with a lot more distortion, unless everything after these stages have already run out of steam.
What I mean to say is there is more to consider. If you point to a specific amp or schematic you're interested in analyzing/tinkering, then it would be easier to show how this stuff works.