Usually when a transformer does burn up, there is operator-error involved somewhere else.
Possible examples include:
Component failure or accidental short-circuit which removes output tube bias (massive plate current, usually killing a tube)
Short-circuit of B+ (usually blows a fuse, unless not installed or over-rated)
Rectifier failure or mis-wiring (may only kill components, but could burn up PT)
Operator error is a definite possibility in my case, but could it possibly have something to do with single coil pickups too?
I have been messing around with this circuit extensively over the past week.
Swapping in different preamp tubes, 12AX7, 12AT7, 12AU7, even the Hammond 1/2 AU7 1/2 AX7 tube.
No problems to report with any of the changes.
The circuit functioned properly at startup with the single coil guitar and the mixed gain Hammond tube.
Swapped to the 12AU7 and it was still functioning well at low gain.
Voltage at 250VDC Current at 30mA.
No spike in current or drop in voltage noted when problem started.
I had the single coil guitar sounding as I went from like 2 on gain to 5.
That is when the problem began. Like I said no current spike or voltage drop noted, and no smoke.
I was watching closely as I turned the gain up.
The problems you mentioned should have shown in voltage or current readings, correct?
Tried a different pre tube and then the output tube no change.
Checked circuit voltages and found the B+ no longer making it through the OT like it should.
Checked OT's primary resistance and found it had increased greatly.
Maybe just a very old OT that finally gave up?
I'd be interested to hear your ideas about what might have gone wrong, HBP.

OK, thinking more on the single coil question.
I forgot that I had been using my Ibanez JEM which has a single coil pickup in the center position exclusively until I broke a string.
No issues then, and shooter has verified using different freqs. with no adverse effects on OT.
So I think my idea of high frequencies from a single coil pickup affecting the OT is out the window now.
It just seemed strange that I had used Humbuckers and even a bass on this circuit with no problems, both up to full gain.
Pull out my son's Jay Turser single coil junker and the OT dies.
Maybe just a very old OT that finally gave up, is seeming more likely to me.
Of course it could still be operator error.
