Did the analysis; unless your effects output a strong signal, you may need a gain stage between the Line In and Volume pot of the Wet Amp.
At the operating point you chose, the 12AY7 has an internal plate resistance of about 37kΩ, and with a 150kΩ plate load will have a gain of about 32
if the cathode resistor is fully bypassed. Mu at the operating point is 40. Gain with the unbypassed 3kΩ resistor will be about 19.4.
The a.c. load of the cathode follower is (I think) immaterial in this circuit. The a.c. load of the common cathode stage feeding the follower is appreciably same-as 150kΩ. So no drawing of a.c. loadlines needed.
As I mentioned before, since you're basically copying the data sheet condition for 350v plate and 250v screen (albeit with a different load), I'll assume the correct bias voltage will be -18v. I've annotated 18v on the cathode and a bias resistor of 320Ω. Those are available in a 3w wire wound from Vishay Dale (and perhaps others).
The output tube will probably make all its clean output and be breaking into serious distortion by the time the peak grid signal equals the bias voltage. So following this rule of thumb, our required peak signal for full output power will be 18v peak at the 6L6 grid.
There is a loss of about 0.8 at the voltage divider formed by R139 & R142, so signal at the cathode follower output must be about 22.6v peak for max clean output.
Gain of a cathode follower is roughly µ/(µ+1), so gain of the 12AY7 cathode follower will be about 0.98. The must be a signal input to the cathode follower of about 23v peak.
As noted earlier, the gain with a fully bypassed cathode resistor is 32, but only 19.4 if unbypassed.
Assuming you add a bypass cap (and delete C122, which would then be a capacitive voltage divider and drop input signal to nothing), a grid input on the 1st 12AY7 stage of 0.72v peak is needed for max clean output.
There is a volume control ahead of the 12AY7, and assuming you want all the clean headroom of the Wet Amp to run out at about "9" on this volume pot, you will need double the input from the Line In as we just previously calculated. So the Line In should receive 1.44v peak (a bit over 1v RMS) for max clean output from this Wet amp. That's a pretty hot line level, consistent with pro audio gear.
All that said, you
can run it just fine with weaker inputs, and everything will work. You won't really max out the clean power of this Wet Amp, but then againYou may be looking to ensure it never distorts. Eliminating R139 will increase the sensitivity of the Line In to about 1.15v peak (0.81v RMS) for maximum clean output.
Adding gain would then give your Volume control a range of adjustment, instead of being full-up all the time. Or you could just eliminate it and replace with a resistor to ground.