In a good design, the hiss (thermal noise) for the entire amp will be dominated by noise from the input tube (triode), because that's where the signal is smallest. That isn't the case for this design, though.
In this case, R1, R2, and R7 are the dominant sources of noise in the entire amp, and that's where I'd start. Even if you'd used metal film resistors in all three places, the resistor values are so big that thermal noise from these three will dominate the noise of the entire amp - the resistors are noisier than V2B, which is just a terrible shame. (Yes, Leonidas used the 68k resistors, because he didn't understand thermal noise.)
So I would suggest replacing R7 with a 10k metal film resistor - this will still work as a grid stopper, but now it hisses no more than V2B, so at least it doesn't make the amp much hissier than it needs to be. As for R1 and R2, do you ever actually use the "Low" input? If not, get rid of them. Replace R2 with a wire jumper or zero-ohm metal film resistor, and remove R1 entirely.
The design of the boost circuit is suspect, too. With your 1M RV1 "Boost" pot at maximum, the 1M pot and 1M resistor (R6) combine to put an enormous source impedance of 500 kilo ohms in series with the grid of V2B. This is a lot of resistance, and it will add a lot of hiss. I would suggest lowering both R6 and RV1 quite a bit; maybe 100k and 100k respectively, and R6 should be a metal-film resistor. That shouldn't load down your boost stage too much, as they present a 200k load to V1 A/B, and since those two triodes are in parallel, they should have a lower-than-usual output impedance anyway (the internal plate resistances of the two triodes are in parallel, lowering the output impedance.)
Whether or not this solves your current hiss problem, it will ultimately make your amp less hissy, when you do find and fix whatever other problem might exist.
If it were me, I would also replace R5, R9, and R10 with metal film resistors. The signal is still pretty small at these locations, and it just makes sense to use the quietest resistors you can.
If you get this far, you've eliminated unnecessary thermal noise where it matters most, and the amp should be much quieter. If it's still too hissy, the next obvious culprit is very large-value resistors in series with the signal: in this case, R14, R25,R26, the mix network for the reverb. These should definitely be metal film; better, they should also be lower in value. (I know, Leo used 3.3M...again, he, or his tech, didn't understand thermal noise.)
Hope this helps!
-Gnobuddy