I don't think that's bad at all. Is that a Tele with single coil PUP's? (And a B bender?) Got a guitar with HB's? And the chassis is open, put a metal shield over the chassis opening, cookie sheet, and see if that helps.
The V2 Grid wire on pin 2 seems to be the thing that is very sensitive to noise... it is making that pretty long run. Would it make sense to try and use a shielded wire here?
V2 pin 2 is the input grid for the PI. So maybe yes. But......
Start from the input jack, V1 pin 2 is a long run,
and it has the lowest signal in the amp. So it's the easiest to corrupt from air born signal/noise. I would try shielded wire on V1 1st, see how that does, then if needed use shielded for the next grid, V1 pin 7. Keep going until you knock out what you find offensive.
Looking at the bias, and help me figure out if I'm doing this right, please...
Plate voltage is 427V. OT CT is 435V. Plate to CT resistance is 186 ohms. Current is 43 mA? Is that right? If I plug those into the robinette calculator, it thinks I'm way hot at 133% of tube rating... my pin 5 measurement is -34.9V.
Am I missing something or doing something weird here, or should I be cutting my bias by half to get down to 22-ish, which the calculator says is 70%?
Don't you have 1 ohm R's on the 6V6 K's? What are they reading? Get that down to ~20mA each, you can always go higher.
I have no idea what your doing here. You don't need plate to CT ohms for anything here.
Rob Rob's bias calculator all you have to do is pick the tube your using and put in the plate dcv, then hit the calculate button. Your looking at the class AB Fixed Bias. I would try 60% dissipation 1st.