By structural geometry, 1/10th is very strong, 1/50 is very weak.
2x2x12" is at least 25" wide. So 2.5" thick is very strong, 1/2" stuff is very weak.
> use 7/16" clear baltic birch
Then run "joists" to cut the span to just the 12"-14" of one speaker. IMHO 7/16" is too thin to span 25" with decent strength and stiffness. A simple 1x3 down the middle will help a lot. The critical detail is getting the "joist hanger" connection (to the sides) VERY strong. (Not like they did in my ceiling....)
> 1/2" ply for the back.
Stuff that WON'T buzz/rattle. Not CDX sheathing, which is like 10% void and a toothpick size splinter in every other void. And again: 25" is too far a span for 1/2" stuff. But since this panel will be half the total weight, you don't want to do 1.25" stuff (oof!). So go to joist bracing, then good 1/2" ply will be acceptable.
> tone comes first
Bah. A four-12 is not about tone, it is about POWER. It is the biggest array which will fit in the Econoline. Even then, it only fits if the front is "all cones". This isn't a Ten in a 18" box, where you can use the panel for acoustic support and woody resonance. The function of a four-12 box is to limit the front-back air slosh, and to connect the four speakers to a handle. As long as it doesn't rattle or wheeze (which can be hard to achieve), there's no "tone" in the box.
Since it will be heavy and loaded in the dark by a tired musician, hopefully distracted by band-chicks, it needs to be drop-proof.
> white pine if you have it
Come on over. I have a slab of pine 29 inches wide and 5 inches thick, 7 feet long. Been curing in the chicken-shed for 15 years, and several years in a good wood shed before that (there's a story). Plane it, bevel it, dowel it with broomsticks, it could be an acoustically sound four-12 baffle. But you better own your own bar.... this would not be portable.