Layout will be more critical due to the high gain. I suggest following one of the many proven board layouts available rather than true point to point.
I agree completely.
Despite how the schematic is drawn, the two 12AY7 sections, U7 and U8 must physically be swapped when built. What I mean is U7 must be closest to the input jack and be the first thing the signal hits, with U8 coming second. If you build with all tubes in a row towards the back edge of the chassis, this won't matter too much, since both sections are part of the same tube.
This is a case where I'd build Matchless-style, if space allowed. What I mean is the old Marshall amps were like the Fender amps, and had the tubes in a row on the chassis, nearest the back panel. But on some models, Matchless positioned the input tube closer to the front panel. It makes for a longer reach to swap that tube when the chassis is in the cabinet, but it shortens the wiring to/from the input jack and front panel controls. If you had space available between the front panel and controls and where the edge of the circuit board is, I'd put that input tube up there between the board and front panel. The wiring to and from the switch to activate U8 is critical. It short be short and probably shielded wire for everything from the input jack to the grid of U6.